{"id":8708,"date":"2013-01-30T22:50:00","date_gmt":"2013-01-30T21:50:00","guid":{"rendered":"https:\/\/service1.8volante.com\/Martin\/?p=8708"},"modified":"2023-05-28T15:32:47","modified_gmt":"2023-05-28T13:32:47","slug":"ask-anakinra-survival-kit","status":"publish","type":"post","link":"https:\/\/www.martin-fleischer.com\/en\/consultancies\/ask-anakinra-survival-kit\/","title":{"rendered":"ASK (Anakinra Survival Kit)"},"content":{"rendered":"\n

In 2010\/2011, shortly after the merger of Swedish Orphan International<\/em><\/strong> with Biovitrum<\/em><\/strong>, I suddenly found myself tasked with managing a scientifically astonishing and extraordinary molecule: anakinra<\/em><\/strong>, a recombinant human interleukin-1 receptor antagonist (rHuIL-1ra<\/em>) – a very peculiar, anti-cytochine, biological anti-inflammatory drug. Although at that time it was licensed only for the treatment of rheumatoid arthritis (after failure of methotrexate), anakinra <\/em><\/strong>already had developed a \u00ablife of its own\u00bb because of its striking efficacy in treating diseases related to interleukin-1 overproduction (mostly due to dysfunction of the inflammasome). In that period, it  was as well used as a diagnostic tool in desperate clinical cases: if the patient responded to a single injection of anakinra, then the diagnosis was to be looked for within IL-1 mediated periodic fever syndromes or similar.<\/p>\n\n\n\n

Managing the available literature upon this drug (thousands of PDFs, ranging from pre-clinical studies via case reports reports to randomized clinical trials) was a highly demanding, surreally difficult undertaking. Consequently, given my passion for software development, I began building a database in MS EXCEL and MS ACCESS of the available literature, later made easily surfable \u00a0as a mini-web-site in HTML\/javascript with intuitive menus. In addition, the system fed citation managers such as Mendeley<\/a>, Endnote<\/a>, Papership<\/a> or Zotero<\/a> by exporting files with standards .RIS<\/a> or .BIB<\/a>. <\/p>\n\n\n\n

\"\"

(pivot-table of entries\/PDFs present in the database)<\/figcaption><\/figure>\n\n\n\n

Very well-structured and easy to use, I toasted CDs that flew off with colleagues of the other affiliates of the company\u2026<\/p>\n","protected":false},"excerpt":{"rendered":"

In 2010\/2011, shortly after the merger of Swedish Orphan International with Biovitrum, I suddenly found myself tasked with managing a scientifically astonishing and extraordinary molecule: anakinra, a recombinant human interleukin-1 receptor antagonist (rHuIL-1ra) – a very peculiar, anti-cytochine, biological anti-inflammatory drug. Although at that time it was licensed only for the treatment of rheumatoid arthritis […]<\/p>\n","protected":false},"author":2,"featured_media":8736,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[136],"tags":[],"_links":{"self":[{"href":"https:\/\/www.martin-fleischer.com\/en\/wp-json\/wp\/v2\/posts\/8708"}],"collection":[{"href":"https:\/\/www.martin-fleischer.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.martin-fleischer.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.martin-fleischer.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.martin-fleischer.com\/en\/wp-json\/wp\/v2\/comments?post=8708"}],"version-history":[{"count":3,"href":"https:\/\/www.martin-fleischer.com\/en\/wp-json\/wp\/v2\/posts\/8708\/revisions"}],"predecessor-version":[{"id":9715,"href":"https:\/\/www.martin-fleischer.com\/en\/wp-json\/wp\/v2\/posts\/8708\/revisions\/9715"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.martin-fleischer.com\/en\/wp-json\/wp\/v2\/media\/8736"}],"wp:attachment":[{"href":"https:\/\/www.martin-fleischer.com\/en\/wp-json\/wp\/v2\/media?parent=8708"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.martin-fleischer.com\/en\/wp-json\/wp\/v2\/categories?post=8708"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.martin-fleischer.com\/en\/wp-json\/wp\/v2\/tags?post=8708"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}